Our study on LUBAC generating heterotypic ubiquitin chains is publihsed in eLife.

The Ikeda lab (MIB, Japan and IMBA, Austria) and the Haselbach lab (IMP,  Austria) published a paper entitled “The linear ubiquitin chain assembly complex LUBAC generates heterotypic ubiquitin chains” in eLife.

In this study, we found that LUBAC generates heterotypic ubiquitin chains (oxyester bond-based branching on the linear ubiquitin chains) dependently on the catalytic site in the HOIL-1L RING2 domain. We also revealed the first 3D structural model of an E3 ligase complex called LUBAC.

This was a work of Alan of his PhD study. Congratulations to everyone who was involved!

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